TEST-KIT OF THE MONTH

Metabolic Analysis Profile (Urine)

The Metabolic Analysis Profile is an important clinical tool for treating imbalances underlying metabolic, nutritional, and neurological disorders. This test assesses four main areas of metabolism: gastrointestinal function and dysbiosis markers, cellular energy production, neurotransmitter metabolites and an assessment of nutrient sufficiency. Using test results, practitioners can design comprehensive, customised therapies to restore optimal metabolic health.

The Metabolic Analysis Profile is a urinary assessment of 39 key organic acids grouped
according to their primary roles in the following four central areas of metabolism.

1. Gastrointestinal Function

This profile measures eight markers that can reveal malabsorption and dysbiosis.
These imbalances can be addressed to improve gut health and to help prevent or
alleviate: Chronic digestive problems, common causes of nutritional deficiency, yeast
overgrowth, cognitive impairment,gastrointestinal distress, and degenerative
conditions.

2. Energy Production

This profile assesses metabolites that serve as important intermediates in the citric acid
(Krebs) cycle. This cycle supplies the body with its primary energy needs, converting
90% of food energy into cellular energy. This subpanel also includes:
• Carbohydrate metabolites that can signal impaired glucose metabolism
• Markers that help evaluate the breakdown of fats and production of cholesterol
• A marker measuring the production of coenzyme Q10
Imbalances of cellular energy metabolites are linked with chronic fatigue, accelerated cell
breakdown, and unhealthy aging.

3. Neurotransmitter Metabolites

A special grouping of neurotransmitter metabolites serve as importantdiagnostic
indicators of abnormal metabolism that can underlie many key aspects of
neuropsychiatric function. These markers are urinary metabolites of powerful
neurotransmitters that act on the central nervous system, including: Epinephrine,
Dopamine, and Serotonin. These substances can profoundly influence patterns of stress
response, emotional well-being, cognition and sleep.

4. Assessment of Nutrient Sufficiency

This test provides a functional assessment of nutrient sufficiency and usage that covers
abroad range of vitamins, coenzymes, elements, enzyme activators and other nutrients.
An analysis of amino acid metabolites which require vitamin and mineral cofactors for
their metabolism can hint at deficiencies of: vitamins B6, B12 and C, magnesium, copper,
iron, and various amino acids.
Metabolic Analysis Testing
• All markers on the Metabolic Analysis Profile are measured in urine and ratio to
creatinine. This allows a single urine sample to be used for analysis.
• The test report includes an in-depth interpretation for abnormal results with a list of
possible remedial nutrients. Customised vitamin& mineral formulas are available.
• The test is available with pediatric (ages 2-12) as well as adult reference ranges.
The Metabolic Analysis Profile is an important clinical tool for treating imbalances
underlying metabolic, nutritional, and neurological disorders. Using test results,
practitioners can design comprehensive, customised therapies to restore optimal
metabolic health

ANALYTE LIST: Isocitric Acid2-Hydroxyphenylacetic Acid / 3-Hydroxyproprionic Acida-Ketoisovaleric Acid / b-Ketoglutaric Acid / Citramalic Acid / Indoleacetic Acid / Lactic Acid / Malic Acid / Pyruvic Acid / 3-Methyl-4-OH-phenylglycola-Ketoadipic Acid / a-Keto-b-Methylvaleric Acid / Cis-Aconitic Acid / Citric Acid / Homogentisic Acid / Kynurenic Acid / Orotic Acid / Phenylacetic Acid / Suberic Acid / Succinic Acid / Creatinine / 4-Hydroxyphenylpyruvic Acid / a-Ketoglutaric Acid / a-Ketoisocaproic Acid / Arabinoseb-OH-Butyric Acid / Formiminoglutamic Acid / Pyroglutamic Acid / 5-OH-Indoleacetic Acid / Adipic Acidb-OH-b-Methylglutaric Acid / Dihydroxyphenylpropionic Acid / Fumaric Acid / Glutaric Acid / Homovanillic Acid / Methylmalonic Acid / Tartaric Acid / Vanilmandelic Acid
Turn Around Time: 21 Days

Specimen Requirements: First morning urine collection; two tubes of 5ml each (samples frozen)